Subcutaneous Peritoneal Access Device for Type I Diabetic Patients Nonresponsive to Subcutaneous Insulin

Subcutaneous peritoneal access device for type I diabetic patients nonresponsive to subcutaneous insulin.

Three type I diabetic patients nonresponsive to subcutaneous insulin were implanted with a subcutaneous peritoneal access device. In these patients, multiple subcutaneous injections had been unable to prevent recurrent hospital admissions for diabetic ketoacidosis. The patients were responsive to intravenous insulin but had limited accessible peripheral veins. Complications of thrombosis and/or...

Intraperitoneal Versus Subcutaneous Insulin Treatment in Diabetic Patients on Continuous Ambulatory Peritoneal Dialysis Therapy

[Benefits of subcutaneous continuous insulin infusion in type 1 diabetic patients with high glycemic variability].

BACKGROUND Hypoglycemia limits the efficacy of intensive insulin therapy, especially in patients with great glucose variability. The extent to which continuous subcutaneous insulin infusion (CSII) overcomes this limitation is unclear. Our aim was to determine whether CSII is helpful for decreasing glucose variability and hypoglycemia, mainly in patients with the greatest variability. METHOD T...

The benefits of metformin therapy during continuous subcutaneous insulin infusion treatment of type 1 diabetic patients.

OBJECTIVE This study was designed to assess the insulin-sparing effect of oral administration of metformin along with a continuous subcutaneous insulin infusion (CSII) for the treatment of type 1 diabetic patients. RESEARCH DESIGN AND METHODS A total of 62 patients (25 women and 37 men) were studied in a monocenter, randomized, double-blind placebo-controlled study, comparing metformin (850 m...

Anti-amyloidogenic and disaggregating effects of Salvia officinalis in vitro: a strategy to reduce the insulin amyloid fibrils due to repeated subcutaneous injections in diabetic patients

Background: Recently, there has been growing efforts to elucidate the molecular mechanism of amyloid formation and investigating effective compounds for inhibiting of amyloid structures. Investigation of the fibrillation process through its induction and inhibition using specific compounds such as aromatic derivatives provide useful information for stabilizing the protein structure. In the pres...